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by Bill Roberts - Nolvadex is very comparable
to Clomid, behaves in the
same manner in all tissues, and is a mixed estrogen
agonist/antagonist of the same type as Clomid. The
two molecules are also very similar in structure.
It is not correct that Nolvadex reduces levels
of estrogen: rather, it blocks estrogen from estrogen
receptors and, in those tissues where it is an antagonist,
causes the receptor to do nothing.
The claim that Nolvadex reduces gains should
not be taken too seriously. The fact is that any
number of bodybuilders have made excellent gains
while using Nolvadex. The belief that it reduces
gains seems to stem from the fact that the scientific
literature reports a slight reduction in
IGF-1 (individuals
using anabolic steroids were not studied though)
from use of Nolvadex. Thus,
Dan Duchaine reported that it reduces IGF-1
and therefore reduces gains. However, if this effect
exists at all, it must be very minor, due to the
excellent gains that many have made, and from the
fact that no one has noticed any such thing from
Clomid, which has the same
activity profile.
However, I would not be surprised if one were
to tell a steroid user that Clomid reduced his gains,
he would immediately become afraid that Clomid reduced
his gains (please note that no one I have ever heard
of has noticed this.) Not having been so misled,
however, he would not conclude this from his results.
But if an authority publishes that such an effect
occurs, whether it does or not it can become self-fulfilling
by biasing the user.
The fact that Nolvadex will reduce water retention
may result in the user agreeing that gains are less,
since weight gain is less, thus reinforcing the
bias.
Tamoxifen citrate is the
chemical name of active ingredient in Nolvadex.
Nolvadex is a registered trademark of AstraZeneca
UK Limited in the United States and/or other countries.
Nolvadex Resources
Tamoxifen Pictures
Nolvadex Prescribing Information
|
|
|
| Trivial name |
Tamoxifen |
| Systematic name |
Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-,
(Z)-
|
| CAS number |
10540-29-1
or 54965-24-1 (citrate) |
| ATC code |
L02BA01 |
| Merck Index Number |
9137 |
| Chemical formula |
C26H29NO
or C32H37NO8
(citrate) |
| Molecular weight |
371.5212
g/mol (without
citrate)
563.6462 g/mol (with citrate) |
| Bioavailability |
|
| Metabolism |
hepatic |
| Elimination half-life |
7 days (metabolite 12 days) |
| Excretion |
hepatic |
| Pregnancy category |
X |
| Legal status |
Prescription only (US) |
| Controlled substance |
No |
| Routes of administration |
Oral |
Bodybuilding eBooks
Beyond Steroids by Anthony Roberts - The Newest and Most Effective Bodybuilding
Drugs
Burn the
Fat, Feed the Muscle by Tom Venuto - Secrets of the World's Best Bodybuilders
& Fitness Models
Chemical Muscle Enhancement by Author L Rea - Bodybuilder's Desk Reference
Chemical Wizardry by George Spellwin - The Definitive Anabolic Steroid and
Physique Enhancement Database
The Layman's Guide
to Steroids - Mick Hart's Anabolic Steroid Guides
Muscle Building Nutrition by Will Brink - Serious Lean Muscle Gains without
the Bodyfat
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