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by Anthony Roberts - GHRP-6 is a peptide
in the growth factor family. It has strong
effect on the release of Growth Hormone (GH).
Its main use is to promote food intake by stimulating
hunger and aid in energy metabolism.
It can be used in the treatment of GH deficiency
as well as cachexia, eating disorders and
obesity.
Background
Although still relatively new, peptides have
recently become popular as performance enhancing
drugs. GHRP-6 is currently available from
a few research companies.
Action
The major side effect accompanied by the use
of GHRP-6 is a significant increase in appetite
due to a stimulating the release of Ghrelin, a peptide
which is released naturally in the lining of the
stomach and increases hunger and gastric emptying.
GHRP-6 causes stimulation of the anterior pituitary
gland which ultimately causes an increase in GH
release. Since GHRP-6 acts directly on the
feedback loop which signals the inhibition of GH
release, when natural GH secretion has been inhibited
by long term synthetic use, GHRP-6 can be used to
re-stimulate the natural production of GH.
GHRP-6 also affects the central nervous system,
by protecting neurons as well as increasing strength
in a way very similar to the way certain steroids
in the Dihydrotestosterone
family do.
Benefits of increased Growth Hormone levels through
GHRP-6 stimulation include: an increase in
strength, muscle mass and body fat loss, rejuvenation
and strengthening of joints, connective tissue and
bone mass. Enhanced GH secretion also leads to the
liver secreting more IGF-1 (Insulin-Like Growth
Factor 1), which is thought to be the primary anabolic
mechanism of action for Growth Hormone.
Technical Data
It has also been discovered that when GHRP-6
and insulin are used simultaneously, GH response
to GHRP-6 is increased (1). A recent study in normal
mice showed significant differences in body composition,
muscle growth, glucose metabolism, memory and cardiac
function in the mice being administered the GHRP-6
(2). There are still many questions regarding
this fairly new compound, scientists are hoping
with to gain a better clinical understanding of
the peptide through further research over the next
few years.
User Notes
I used this stuff at a dose of 500-600 mcg/day
for awhile and found that the weight gain (mostly
from an increase in my appetite) was far too great.
I gained a ton of weight (on par with the most potent
anabolics) but it wasn’t pretty.
The effects on my joints were very beneficial
at that dose also, but I didn’t really find much
of a drop off when I lowered the dose to 100-200
mcg/day. In fact, I have a sprinter friend who ran
a personal best with a combination of low dose GHRP-6
(100-150 mcg/day or so) and Anavar (20 mgs); that
wouldn’t be a huge deal but for the fact that this
was done while rehabilitating an injury!
On the other hand, even that low dose was too
much for a figure competitor I know, who gained
far too much weight from using GHRP-6 and ultimately
had to discontinue using it after only a couple
weeks.
Although this stuff can have GH-like effects,
the weight increase makes any possible fat burning
effects almost unnoticeable. For a bulking cycle,
and at the price, it’s almost a must-have, if you’re
looking to gain a ton of weight or trying to rehab
an injury.
| Substance name |
SK&F 110679; Growth Hormone
Releasing Hexapeptide (GHRP-6) |
| Chemical name (sequence) |
histidyl-tryptophyl-alanyl-tryptophyl-phenylalanyl-lysinamide;
{HIS}{d-TRP}{ALA}{TRP}{d-PHE}{LYS}-NH2 |
| Systematic name |
(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenyl-propanoyl]amino]hexanamide |
| Index name |
L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl- |
| CAS Number |
87616-84-0 |
| Merck Index Number |
N/A |
| Molecular formula |
C46-H56-N12-O6 |
| Molecular weight |
873.026 |
| Legal Status |
?? |
| Route of Administration |
Subcutaneous injection,
Intramuscular Injection |
References
- Penlava, A, et. al. Effect of growth hormone
(GH)-releasing hormone (GHRH), atropine, pyridostigmine,
or hypoglycemia on GHRP-6-induced GH secretion
in man.J Clin Endocrinol Metab. 1993 Jan;76(1):168-71.
- Adeghate, E. & Ponery, A.S. (2002) Ghrelin
stimulates insulin secretion from the pancreas
of normal and diabetic rats. Journal of Neuroendocrinology,
14, 555560.
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