by Anthony Roberts -- Dostinex (Cabergoline)
is a dopamine agonist. Dopamine is a chemical, found
in the brain, which transmits nerve impulses and
is involved in the formation of epinephrine. More
likely than not, this is why the Life-Extentionistas
are very big on this drug. Dopamine is also released
by the hypothalamus, and hormone can inhibit the
release of prolactin from the anterior lobe of the
pituitary, so given all the bad things that we have
already seen to be a result of excess. If you use
anabolic steroids, Dostinex will help you reduce
the chance of any of these prolactin related side-effects.
It has actually been shown in numerous studies to
have a very high success rate in lowering prolactin
and prolactin related conditions and side-effects
(1) (2).In fact, for management of hyperprolactinemia
and it’s symptoms (got milk?), Dostinex is the preferred
treatment in terms of effectiveness as well as having
very few undesirable side effects (3). It
does this very well for both men and women, it should
be noted…almost identically actually (4)
Since it lowers prolactin very efficiently, Dostinex
will even get rid sexual dysfunction caused by excess
prolactin (5) (which is (anecdotally at least) highly
correlative with the use of certain steroids like
the Nandrolones
and Trenbolones (Deca
and Tren). This is great news for everyone who loves
Tren and Deca, because those two steroids are really
great additions to almost any cycle- but many people
avoid using them because of the possibility of them
causing impotence (often called “deca dick”).
Using Dostinex will allow you to include steroids
like Tren and Deca in any cycle- and even combine
them in the same cycle- without worrying about sexual
dysfunction. In fact…even if you aren’t experiencing
any sort of sexual dysfunction, Dostinex will shorten
the time you need to recover and gain an erection
between orgasms, and can significantly enhance all
parameters of sexual drive and function (6). In
other words, if you’re not worried about sexual
issues and you take Dostinex anyway…it’ll still
help you out in bed. And from what I have heard,
it’s well worth the money for that effect.
Of course you can actually use Dostinex safely
for an extended amount of time (many studies go
on for months if not years, and its efficacy and
safety are well documented), but women need to be
more careful than men, and certainly need to discontinue
using it if they’re pregnant or trying to conceive.
SO Dostinex can help you, the average steroid user,
by combating gyno-like effects, as well as galactorrhea,
and sexual dysfunction. Sounds great, right? Of
course it is…but since Dostinex is a dopamine agonist,
which means it’s good for a whole lot more.
You see Dopamine is what’s called a monoamine,
which is naturally produced in the body by modifying
an amino acid.
Dopamine
And it’s this structure which makes it very interesting
to us. Dostinex as you already know is what’s known
as a dopamine “agonist”- or substance that triggers
a response in a specific body tissue or group of
cells by binding to specific receptor on or inside
the cells, as if it were actually the bodily substance
that usually binds to that receptor. Probably the
one that most people are familiar with, with regards
to agonists is ephedrine, which is an andrenergic
agonist. This is why ephedrine makes you feel “wired”…it
“feels” like adrenaline to your body. Cabergoline
is a dopamine agonist…which makes it “feel” like
dopamine to your body.
Dostinex
So what does that mean? Well, in the brain, dopamine
helps control the flow of information from other
areas of the brain. So a dopamine agonist will help
you process information more quickly, and possibly
improve your memory also. Some athletes use Dostinex
because it helps them learn new motor skills more
quickly and thus they can learn new techniques or
plays at a faster rate than their competition; needless
to say this gives the athletes using Dostinex a
huge advantage over their competition. This ability
to work on your bodies information pathways and
nervous system are doubtless why it’s been successfully
been used to fight Parkinsons disease (7)(8).
But does this actually work in real athletes?
Well, actually, that’s why I started reading about
Dostinex. See, I have the fortune of being able
to basically call some of the most famous strength
coaches in the world whenever I want. And, recently
the last time I spoke to one about training and
anabolic steroids, I asked him about different training
programs for a person on steroids- and his answer
said that it depends on whether that person was
taking a nootropics or not. And as you may remember,
Dostinex is a nootropic. It was that conversation
that made me really take a closer look at Dostinex.
And of course, that strength coach told me that
his athletes have used nootropics with great success.
The down side of knowing internationally renowned
strength coaches is that their sense of humor is
usually a little off, and if you have the fortune
of being able to pick their brains on training,
you also invariably have the misfortune of ending
up on their group e-mail list which gets you a whole
host of bizarre forwarded e-mails…
In fact, when you don’t have enough dopamine,
you may even have difficulty concentrating…low dopamine
levels have also been cited as a possible underlying
cause for Attention deficit disorder (ADD) and Attention
deficit/ Hyperactivity disorder (ADHD). In fact,
many several medications used to treat ADD and ADHD
will also serve to stimulate dopaminergic, and this
could be one of their possible mechanisms of action.
Dopamine is also what’s called a “pleasure chemical”…it’s
usually released by your body when you experience
a rewarding experience such as eating your favorite
food, having sex, winning the lottery….whatever.
Interestingly, since this “happy” effect is felt
when you are satiated from food, it’s highly possible
that Dopamine agonists will cause you to feel “full”
more often and decrease desire for food without
the discomfort that dieting usually brings. Dopamine
is released when you eat a nice big meal…so…a dopamine
agonist like Dostinex may make you not want to eat
as much, and help you feel full even if you don’t
eat enough. Dostinex, therefore, may be of great
interest to precontest bodybuilders and other dieters,
who want to avoid some of the discomfort and anxiety
that calorie restriction can bring.
Certain recreational drugs also have a lot to
do with their effects on dopamine. Cocaine is what
is known as a dopamine transporter blocker; what
this means is that it competitively inhibits dopamine
uptake to increase the amount of time released dopamine
is active in your body. This makes you feel good,
while the dopamine is floating around your body.
Methamphetamine is another illicit (illegal) recreational
drug that acts on dopamine as well. It actually
serves to competitively inhibit dopamine uptake
as well as increasing dopamine flow through a dopamine
transporter pathway. That’s how those drugs make
you “feel good.” Dostinex is, of course, neither
physically nor mentally addictive, but since it
is a dopamine agonist, its users often experience
an enhanced positive sense of well being. So besides
helping with all of the things discussed earlier,
Cabergoline will also just make you feel damn good.
So now that I told you about it, I’ll tell you
how much Dostinex do you need to start experiencing
these effects…or basically, how I’m going to use
it, now that I did all this research on it!
From the reading I’ve done, you only need about
half a milligram (1/2mg) a week to experience all
of the anti-prolactin, prosexual, antidepressant,
and cognitive effects of Dostinex, but that’s on
the very low end of the effectiveness scale. This
stuff has an extremely long active life in the body,
so once a week dosing is fine…but if it were me,
and I were taking this stuff, I’d probably be using
about .25mgs-.5mgs twice a week.
It should be taken before bed-time, because it
may actually help you sleep a bit better, (9), Can
be taken with or without food and not alter the
pharmacokinetics (how it functions in your body)
(10), and (incidentally) according to the literature
is a much more efficient drug than
Bromocriptine (11).
I think once people find out about this drug, it’s
going to find it’s way into quite a few bodybuilders’
cycles alongside Tren,
Deca, or both…and
athletes are going to take advantage of it’s uses
for skill acquisition and motor co-ordination help…and
all the other stuff…the prosexual properties and
general “feel good” properties of Dostinex make
it a great choice for anyone interested in …err…feeling
good and having better sex…which I suspect is basically
everyone, not just bodybuilders and athletes. I
guess I should have paid more attention to this
stuff when it started appearing on those Life-Extension
club pricelists a decade ago…but at least I figured
it out now….even if I happen to be a bit late on
this one.
Cabergoline is the chemical name of
active ingredient in Dostinex. Dostinex
is a registered trademark of Pfizer Inc. in the
United States and/or other countries.
Dostinex Prescribing Information
